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Calidi Biotherapeutics Collaborates with SIGA Technologies to Develop RTNova Virotherapy for Lung Cancer and Metastatic Solid Tumors

Tuesday, June 11, 2024

Calidi Biotherapeutics, Inc. (NYSE American: CLDI), a biotechnology firm focused on clinical-stage research, is developing the RTNova (CLD-400) virotherapy platform aimed at creating innovative cancer treatments. The company recently entered into a partnership with SIGA Technologies (Nasdaq: SIGA) to advance this platform, which has the potential to be a comprehensive treatment for a variety of cancers. Initially, Calidi will concentrate on lung cancer and metastatic solid tumors, which represent significant causes of cancer mortality.

The collaboration will utilize SIGA’s expertise with TPOXX, an antiviral agent approved for treating vaccinia virus, to potentially act as a safety mechanism for managing the RTNova virotherapy’s distribution within the body.

Calidi Biotherapeutics, highlighted the innovative potential of RTNova in targeting tumors and modifying the tumor immune environment. “By collaborating with SIGA, we gain access to a safety control that could build trust among patients, doctors, and regulatory bodies throughout the clinical trial phases,” Santidrian stated.

RTNova employs an enveloped vaccinia virus that is engineered to survive in the bloodstream, target various tumor locations, and eliminate cancer cells. This approach not only simplifies the administration of the treatment but also broadens the potential patient base who could benefit from this new therapeutic strategy.

The FDA approved TPOXX in July 2018 for the treatment of smallpox, acknowledging its effectiveness in preventing outbreaks and counteracting bioterrorism. Studies have demonstrated TPOXX’s efficacy against all tested orthopoxviruses, including vaccinia, supporting its potential in developing vaccinia-based cancer treatments.



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